clooneyleatherheads.jpg The gambling drama 21 was once again the box office champ, generating $15.1 million in ticket sales during its second week in release. The Kevin Spacey vehicle has now earned a cumulative total of $45.53 million domestically.

Second place went to newcomer Leatherheads, a romantic comedy about pro football in the 1920s that stars George Clooney and Renée Zellweger. The film earned a disappointing $13.4 million to barely edge out fellow newcomer Nim’s Island.

The only other new release to debut in the top 10 was the Carter Smith horror/thriller The Ruins, which sold $7.8 million in tickets — good enough for fifth place this week.

Here’s the complete top 10 at the box office for 4/6/08

  1. 21, $15.1 million
  2. Leatherheads, $13.4 million
  3. Nim’s Island, $13.3 million
  4. Horton Hears a Who!, $9.1 million
  5. The Ruins, $7.8 million
  6. Superhero Movie, $5.4 million
  7. Meet the Browns, $3.5 million
  8. Drillbit Taylor, $3.4 million
  9. Shutter, $2.8 million
  10. 10,000 B.C., $2.7 million